Andy is a consultant in nephrology and general internal medicine dividing his time between clinical work, teaching and academic research. He leads the renal genetic and tubular diseases service in Addenbrooke's hospital Cambridge, a tertiary service, that specialises in a variety in rare renal diseases including electrolyte abnormalities, cystic kidneys, recurrent renal stone formation and genetic conditions. He also carries out a significant amount of acute general medical and renal inpatient work.
Academically he works with Professor Menna Clatworthy in the MRC laboratory of molecular biology with interest in renal tubular disease, non invasive renal biomarkers, and urinary tract innate immunology and UTI defence.
Within Christ's, Andy is the director of studies for medicine with responsibility for all of the college's ~85 medical students. He supervises the pharmacology and renal physiology courses for first and second year students.
Selected Publications:
Stewart, A.P., Loudon, K.W., Routledge, M., Lee, C.Y.C., Gillman, E., Trotter, P., Richoz, N., Antrobus, R., Mccaffrey. J., Posner, D., Conway Morris, A., Karet Frankl, F.E., Clatworthy, M.R. (2024) Neutrophil extracellular traps protect the kidney from ascending infection and are required for a positive leukocyte dipstick test. Sci. Transl. Med. 16, 766.
Stewart, A.P and Clatworthy, M.R. (2023) Single-cell genomics sheds light on kidney tissue immunity. Nat. Rev. Nephrol. 20, 71-72.
Stewart, A.P., Sandford, R.N., Karet Frankl, F.E., Edwardson. J.M. (2014) Pathogenic uromodulin mutations result in premature intracellular polymerization. FEBS Lett. 589, 89-93.
Stewart, A.P., Gómez-Posada, J.C., McGeorge, J., Rouhani, M.J., Villarroel, A., Murrell-Lagnado, R.D., Edwardson, J.M. (2012) The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement. J. Biol. Chem. 287, 11870-11877.
Stewart, A.P., Haerteis, S., Diakov, A., Korbmacher, C., Edwardson, J.M. (2011) Atomic force microscopy reveals the architecture of the epithelial sodium channel (ENaC). J. Biol. Chem. 286, 31944-31952.
Stewart, A.P., Smith, G.D., Sandford, R.N., Edwardson, J.M. (2010) Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer. Biophys. J. 99, 790-797.
Stewart, A.P., Egressy, K., Lim, A., Edwardson, J.M. (2010) AFM imaging reveals the tetrameric structure of the TRPM8 channel. Biochem. Biophys. Res. Commun. 394, 383-386.
