Tony is an Academic Clinical Lecturer in Intensive Care Medicine. He is interested in how critical illness of multiple aetiologies impairs the short- and long-term reconstitution of the immune system by the developing haematopoietic compartment, and how this contributes to dysregulation of myeloid functional capacities, resulting in inability to clear primary infections, susceptibility to secondary infections, and life-threatening organ failure.
Sepsis remains an important cause of mortality worldwide, and 40% of critically ill patients with sepsis progress to chronic critical illness with prolonged dependence on organ support, which culminates in an indolent death. Tony aims to understand the mechanism of transition to, and perpetuation of, this debilitating phenotype, using a variety of approaches to study this phenomenon, from primary and immortalised, genetically tractable cellular models to biological samples from patients, who are ultimately the best models of human disease.
Tony is also active in medical education, having supervised for Christ’s College since 2013 in IA physiology, IB immunology, and clinical medicine. Clinically, he enjoys procedural skills and resuscitation, simulation, championing the use of point-of-care ultrasound, and caring for the sickest patients from all disciplines.
Selected Publications:
Woodward JM, Gkrania-Klotsas E, Cordero-Ng AY, Aravinthan A, Bandoh BN, Liu H, Davies S, Zhang H, Stevenson P, Curran MD, Kumararatne D. The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency. Am J Gastroenterol. 2015 Feb;110(2):320-7.
James Melhorn, Andrew Achaiah, Francesca M. Conway, Elizabeth M. F. Thompson, Erik W. Skyllberg, Joseph Durrant, Neda A. Hasan, Yasser Madani, Prasheena Naran, Bavithra Vijayakumar, Matthew J. Tate, Gareth E. Trevelyan, Irfan Zaki, Catherine A. Doig, Geraldine Lynch, Gill Warwick, Avinash Aujayeb, Karl A. Jackson, Hina Iftikhar, Jonathan H. Noble, Anthony Y. K. C. Ng et Al. Pneumomediastinum in COVID-19: a phenotype of severe COVID-19 pneumonitis? The results of the United Kingdom (POETIC) survey. European Respiratory Journal Jan 2022, 2102522; DOI: 10.1183/13993003.02522-2021
Ahmed M, Malik S, Ng AYK, Tariq SM. Audit of Documentation of Chest Drain Insertion Procedures Before and After Introduction of a Chest Drain Pro forma. Clinical Audit. 2023;15:1-5 https://doi.org/10.2147/CA.S398594
Ng AYKC, Fox E, Brelstaff J, Frontini M, Summers C. Efficient Methods for Target Gene Manipulation in Haematopoietic Stem Cell Derived Human Neutrophils. bioRxiv https://doi.org/10.1101/2023.06.17.545406
Röder M, Ng AYKC, and Conway Morris A. Bronchoscopic Diagnosis of Severe Respiratory Infections. J. Clin. Med. 2024, 13(19), 6020; https://doi.org/10.3390/jcm13196020